Correlation of HbA1C Levels With Body Mass Index in Newly Diagnosed Polycystic Ovary Syndrome

INTRODUCTION Polycystic ovary syndrome (PCOS) is a heterogeneous, multisystem endocrinopathy in women of reproductive age manifested with various metabolic disturbances and a wide spectrum of clinical features such as obesity, menstrual abnormalities and hyperandrogenism. Hyperinsulinemia was noted in 50% to 70% of PCOS patients and plays a central role in the development of further complications. The prevalence of obesity in PCOS ranges from 38% to 87%. It has been reported in previous studies that the prevalence of insulin resistance (IR) is higher in obese PCOS women than obesity without PCOS. OBJECTIVE To correlate HbA1c levels with body mass index (BMI) in newly diagnosed polycystic ovary syndrom (PCOS) women. MATERIAL AND METHODS This case-control study performed at Pt. B. D. Sharma PGIMS, Rohtak includes 30 newly diagnosed PCOS patients and 30 age matched healthy controls of any age. Fasting venous blood samples were obtained for analysis of fasting blood glucose, haemoglobin and HbA1c after obtaining written consent. RESULTS HbA1c concentration was higher in cases (6.03±0.19%) than in controls (5.35± 0.08%) with p = 0.002. 33.3% were in pre diabetic range (5.7-6.4%), 36.7% in diabetic range (≥6.5%) and 30% in non diabetic range (<5.7%). BMI of cases (26.09±4.2 kg/m2) was significantly higher than controls (22.9±3.3 kg/m2) with p=0.002. HbA1c showed positive correlation with BMI (p= 0.001). CONCLUSION In conclusion, BMI is associated with glycemic control in PCOS.